ABSTRACT
A metabolic perturbation which occurs in the liver early after the administration of peroxisome proliferators to rats is lipid accumulation. This has been observed in rats given clofibrate, fenofibrate and DEHP (Price et al., 1982; Mann et al., 1985; Mitchell et al., 1985; Price et al., 1986). LY171883, around which much of our work has centred, also causes hepatic lipid accumulation (Foxworthy et al., 1990). Hepatic triglycerides increased after 1 day in rats given 0.3% LY171883 in the diet but returned to control levels with continued treatment (Figure 15.1(a)). In contrast, the lipid accumulation increased progressively in rats given 0.1% LY171883. After 3 months of 0.1% LY171883 there were numerous large lipid vacuoles primarily in the midzonal hepatocytes (Figure 15.2). There were few, if any, lipid droplets in hepatocytes of rats given 0.3% LY171883.
