ABSTRACT
In humans, the thrombotic event frequently consists of multiple cycles of temporary occlusion and reperfusion. The degree of chest pain varies among patients, so that it is often difficult to determine the exact duration of the coronary occlusion. Nevertheless, data indicate that evolution of (enzymatically detectable) infarct size over time in humans shows a pattern similar to that in animals. In a study involving 1334 myocardial infarction (MI) patients, the cumulative release of myocardial -hydroxybutyrate dehydrogenase during the first 72 hours after infarction was comparatively small in those treated within 1 hour from onset of symptoms (Fig. 7.2).8
