ABSTRACT
Human skin has many functions and its condition/appearance often gives clues to systemic disease that may or may not be otherwise clinically evident. For this reason, it is of benefit to discuss the role of the skin as it relates to internal disease. Features of skin involvement in systemic disease may include primary lesions such as papules, plaques, nodules, vesicles or bullae, or may be secondary such as pruritus, redness, hyperkeratosis, or hyperpigmentation.
