ABSTRACT

Arginine Metabolism ...............................................................................................87 Arginine and Wound Healing Metabolism .............................................................89 Arginine and Immune Function ..............................................................................93 Arginine and Sepsis.................................................................................................93 Arginine Clinical Recommendation ........................................................................95 Future Recommendations ........................................................................................96 References................................................................................................................96

Arginine was first isolated from lupin seedlings in 1886 and was thereafter identified as a component of animal proteins. Arginase, the enzyme that hydrolyzes arginine to ornithine and urea was identified in liver in 1904. Later, the discovery of the urea cycle by Krebs and Henseleit in 1932 elucidated the role of arginine in physiology and metabolic pathway.