chapter  5
Hereditary cancers
WithF. Macdonald, C.H.J. Ford, A.G. Casson
Pages 25

Genetic factors are likely to be the primary determinants of the cancer seen in around 5–10% of cancer patients. The identification of some of these cancer susceptibility genes has revolutionized our understanding of cancer in general as described in other chapters. However it has also allowed us to improve our management of patients in those families with a genetic predisposition by offering presymptomatic testing and hence early intervention and treatment for the disease. This chapter will describe the clinical usefulness of the tumor suppressor genes whose biological function was described in Chapter 3 as well as give an example of one oncogene which has been associated with familial cancers.