ABSTRACT
Long-term sequelae of polycystic ovary syndrome (PCOS) are a major concern of affected women, and offer an opportunity for clinical intervention and prevention. The relationship between PCOS and many of its proposed sequelae, however, rest primarily on shared risk profiles until we have confirmation from epidemiological studies. The tendency in the literature and in clinical practice is to assume the worst and intervene. This chapter will examine a variety of sequelae in women with PCOS linked to insulin resistance, including diabetes and heart disease. The risk, however, is often implied based on case series or small inferential studies.
