ABSTRACT

Atherosclerosis and its related complications, coronary heart disease (CHD), myocardial infarction and stroke, have been identified as the major causes of mortality and morbidity in the Western world. Atherosclerosis is a progressive build-up of fatty streaks on the interior arterial walls that prevents adequate blood supply to the myocardium. Although many factors are involved in atherosclerosis, oxidation of low-density lipoprotein (LDL) by free radicals may initiate the lesions and lead to the development and progression of cardiovascular disease (CVD).