ABSTRACT
Parkinsonism, tremor, chorea-ballismus, dystonia, tardive dyskinesia, myoclonus, tics, and akathisia can be induced by many drugs. The drugs that are most frequently implicated in movement disorders are antipsychotics, calcium channel antagonists, orthopramides and substituted benzamides (e.g., metoclopramide, sulpiride, clebopride, domperidone), CNS stimulants, antidepressants including the selective serotonin uptake inhibitors, anticonvulsants, antiparkinsonian drugs, and lithium. Moreover, extrapyramidal reactions (EPR) have also been reported to occur with the selective serotonin-reuptake inhibitors, and motor dysfunction is caused by tacrine.1-17 It is possible for a single drug, such as one of the antipsychotics, to induce two or more types of movement disorders in the same patient. Movement disorders are not always reversible after drug withdrawal.
