ABSTRACT

The Pulmonary Route of Drug Delivery...............................................................259 Anatomy and Physiology of the Respiratory System...........................................260 Lipid-Based Pulmonary Delivery..........................................................................263 Solid Colloidal Particles ........................................................................................267 Poly(dl-lactide-

co

-glycolide) .................................................................................267 Polycyanoacrylates ................................................................................................269 Gelatin....................................................................................................................270 Poly(ether-anhydrides)...........................................................................................271 Diketopiperazine Derivatives.................................................................................272 Polyethyleneimine (PEI)-DNA Complexes...........................................................272 Poly(ethylene glycol) Conjugates..........................................................................273 Factors Affecting Pulmonary Dosing....................................................................274 Conclusions............................................................................................................277 References and Further Reading ...........................................................................278