ABSTRACT

Contributors ................................................................................................................................................ vii

Introduction ................................................................................................................................................ xi

SECTION I HOST DEFENSES

1. Treatment strategies for solid tumors and impact on host defenses Margret Merino and Crystal L Mackall .............................................................................................. 3

2. Treatment strategies for hematological malignancies: Impact on host defenses and infection risk Ivana Gojo, Clarence B Sarkodee-Adoo, Roger R Hakimian, William G Merz and Judith E Karp ...... 17

3. Blood and marrow transplantation Leona Holmberg ................................................................................................................................ 37

SECTION II INFECTIOUS SYNDROMES

4. Infectious syndromes in solid tumor therapy James A Talcott and John R Wingard ................................................................................................ 55

5. Infectious complications in patients receiving cytotoxic therapy for acute leukemia: History, background and approaches to management Eric J Bow .......................................................................................................................................... 71

6. Infections in chronic leukemias and other hematological malignancies Farhad Ravandi, Elias Anaissie and Susan O’Brien ............................................................................ 105

7. Infections in hematopoietic stem cell transplant patients Elizabeth Reed.................................................................................................................................... 129

SECTION III MANAGEMENT STRATEGIES

8. Infections caused by gram-positive cocci and gram-negative rods Jacob Strahilevitz and Dan Engelhard ................................................................................................ 147

9. Management strategies for infections caused by Candida species

10. Invasive aspergillosis complicating neoplastic diseases and hematopoietic stem cell transplantation Thomas J Walsh and Kieren A Marr .................................................................................................. 179

11. Fungi other than Candida and Aspergillus Pranatharthi H Chandrasekar ............................................................................................................ 203

12. Management strategies for herpes simplex viruses in cancer patients and hematopoietic stem cell transplant recipients Richard J Whitley .............................................................................................................................. 223

13. Management strategies for varicella-zoster infections in patients with cancer Paula W Annunziato and Anne A Gershon ........................................................................................ 233

14. Management of CMV infection in hematopoietic stem cell transplant recipients Morgan Hakki and Michael Boeckh .................................................................................................. 247

15. Epstein-Barr virus infections in the oncology patient Farid Boulad, Diane George, Trudy N Small and Richard J O’Reilly.................................................. 269

16. Respiratory viruses in immunocompromised hosts Laurent Kaiser.................................................................................................................................... 287

17. Hepatitis virus infections in patients with cancer George KK Lau, Simone I Strasser and George B McDonald.............................................................. 321

SECTION IV OTHER THERAPIES

18. Use of hematopoietic growth factors in the management of infection in oncology patients Dean McGaughey and Jeffrey Crawford ............................................................................................ 345

19. Granulocyte (neutrophil) transfusion therapy W Conrad Liles, Kai Hubel and David C Dale .................................................................................. 363

20. Uses of immunoglobulins in the management of infection in oncology patients Helen Leather .................................................................................................................................... 373

21. Infection control Gianna Zuccotti and Kent Sepkowitz ................................................................................................ 405

22. Vaccinations in oncology patients Per Ljungman .................................................................................................................................... 417

23. Transfusion considerations Lawrence T Goodnough and John F DiPersio .................................................................................... 431