ABSTRACT
Patients with PCOS are extremely sensitive to the administration of exogenous gonadotrophins during fertility treatment, and are consequently at increased risk of developing OHSS.1 For women with PCOS, it is thought that whilst the initial steps of folliculogenesis may be functional, the selection of a dominant follicle for ovulation does not always occur.2 In υitro maturation of immature oocytes is currently being developed as a potential method for the management of these patients. To date, successful pregnancies have been achieved using immature oocytes recovered from natural cycles,3 stimulated cycles4 and patients with PCOS.5 However, in terms of the number of mature oocytes obtained, the efficiency of the in υitro maturation process does not yet approach that for controlled ovarian stimulation for IVF.
