ABSTRACT

The contribution of the immune system to the fine-tuning of the implantation process of the embryo and the continuation of pregnancy until the birth of a healthy baby has long been of interest to reproductive biologists and clinicians. It was considered that modulation in the function of immune system has to be during pregnancy for a successful outcome. The inefficiency in this modulation and an unusual type of modulation in the function of immune system were also considered as probable causal factors particularly for an unsuccessful outcome in the therapy of unexplained infertility Many descriptive studies imply a role for immunology in reproductive success and failure, although the precise mechanisms of such a role remains insufficiently defined.