ABSTRACT
Oocyte quality is perhaps the single most limiting factor in fertility. It is logical that alteration in oocyte cytoplasm and especially adverse changes in intermediary metabolism may be the source of some oocyte defects. Cytoplasmic transfer (CT) and nuclear transfer (NT) are techniques whereby an attempt is made to correct cytoplasmic abnormalities allowing a couple a chance to have a child without use of donor oocytes. However, CT and NT are much more than a new infertility treatment. They represent two new probes into the ethics and basic science of human reproduction.
