ABSTRACT
Haybittle JL, Brinkley D, Houghton J, et al. Postoperative radiotherapy and late mortality: evidence from the Cancer Research Campaign trial for early breast cancer British Medical Journal 1989; 298:1611-1614. [Similar findings were seen in this CRC trial using orthovoltage radiotherapy.]
Rutqvist LE, Lax I, Fornander T, Johansson H. Cardiovascular mortality in a randomized trial of adjuvant radiation therapy versus surgery alone in primary breast cancer. International Journal of Radiation Oncology, Biology, Physics 1992: 22:887-896. [Similar findings were seen in this Stockholm trial and related to the volume and dose of irradiation to the heart.]
Nixon AJ, Manola J, Gelman R, et al. No long-term increase in cardiacrelated mortality after breast-conserving surgery and radiation therapy using modern techniques. Journal of Clinical Oncology 1998; 16:1374-1379. [In contrast, no increase in cardiovascular deaths were seen in this series using current techniques and megavoltage radiotherapy.]
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This article provided very long-term (up to 34 years) follow-up from a carefully performed randomized clinical trial with very few patients lost to follow-up.
