ABSTRACT

Medical castration by indirectly inhibiting ovarian function at the hypothalamic-pituitary level can achieve similar results in advanced breast cancer to those achieved by surgical oophorectomy.

Hayward JL, Atkins HJB, Falconer MA et al. Clinical trials comparing transfrontal hypohysectomy with adrenalectomy and with transethmoidal hypohysectomy. In: Clinical Management in Advanced Breast Cancer. Second Tenovus Workshop ( Joslin CAF, Gleave EN, eds). Cardiff: Alpha Omega Alpha Publishing, 1970: 50-53.