ABSTRACT

The immune system has two main functions; to recognize invading pathogens and then to trigger pathways that will destroy them. The humoral immune system relies on B lymphocytes to produce soluble antibodies that will bind the foreign antigens. The cellular immune system uses killer T lymphocytes that recognize and destroy invading cells directly. The primary immune response occurs on initial contact with a foreign antigen and results in production of immunoglobulin M and then immunoglobulin G. If the same antigen is encountered again, immunological memory leads to a secondary immune response that produces a much more rapid and larger increase in specific IgG production. A large number of antibody-producing cells exist in an animal even before it encounters a foreign antigen, each cell producing only one specific antibody and displaying this on its cell surface. Antibodies bound to an invading microorganism activate the complement system via the classical pathway.