ABSTRACT
The subject of the synthetic chemistry of nitroxides covers areas including methods of nitroxide group design and syntheses of the nitroxide radicals of different structures as well as reactivity of either the nitroxide group itself or the paramagnetic molecule as a whole. Synthetic chemistry of nitroxides definitely plays a fundamental role in nitroxide applications as well, providing ground for making the use of nitroxides for solving different applied problems possible. The stability of the nitroxide group itself originates from the strong three-electron nitrogen-oxygen bond. The most powerful impetus for development of nitroxide chemistry came from physical chemistry and biochemistry, specifically the successful application in biological studies by Hamilton and McConnell of the spin labeling method based on Electron paramagnetic resonance spectroscopy. The synthetic methods brought to life as the result of the nitroxide chemistry development led to a significant amount of various nitroxide types and derivatives, some of which are commercially available.
