ABSTRACT
2.a.1. Fuxe, F., Everitt, B. J., and Hökfelt, T., Enhancement of sexual behavior in the female rat by nicotine, Pharmacol. Biochem. Behav., 7, 147—151, 1977. Ovariectomized rats were treated with estradiol for 5 days and were then injected (i.p.) with nicotine (0.01, 0.05, 0.10, or 0.25 mg/kg). The lowest dose did not affect sexual behavior. The 0.10 mg/kg dose increased sexual “soliciting” (hopping, darting, or ear-wiggling) and lordosis the most. The highest dose also increased lordotic responding, but this increase was due to depressed motor activity and may have been due to passive acceptance of the male. The increased sexual responsiveness was blocked if mecamylamine (a cholinergic antagonist) was administered shortly before nicotine.20
