chapter  8
38 Pages

Dermatotoxicity: Predictive Models

ByEdward J. Calabrese

Governmental concern over the safety of the materials used as ingredients of various cosmetics first became embodied in legislation over 40 years ago, in 1938, when the U.S. Food and Drug Act became amended to include cosmetics (Giovac-chini, 1972). Cosmetics were considered to be

. . . articles, including components of any such articles, intended to be rubbed, poured, sprinkled, or sprayed on, introduced into, or otherwise applied to the human body or any part thereof for cleansing, beautifying, promoting attractiveness, or altering the appearance.