ABSTRACT
The activities of glycerol phosphate acyltransferase, diacylglycerol acyltransferase, and CTP :phosphocholine cytidylytransferase may change relative to that ofphosphatidate phosphohydrolase. The ability of phosphatidate phosphohydrolase to translocate onto membranes in response to an increased fatty acid availability has been described in liver, lung, and adipose tissue. The increase in the phosphohydrolase activity that occurs in the liver in stress conditions is probably a protective mechanism that provides it with the capacity to cope with an increase in fatty acid supply by being able to synthesize large quantities of triacylglycerol. The elucidation of this problem depends very much on the complete purification of the phosphohydrolase, its characterization, and the availability of antibodies that can be used to detect any covalent modification. Such studies will provide a clearer picture of how phosphatidate phosphohydrolase contributes to the overall integrated control of glycerolipid metabolism.
