ABSTRACT
This chapter explores the some gene expression during the aging in mammals. Three types of changes may occur in the expression of genes as an organism ages: those whose expression decreases, those whose expression increases, and those whose expression does not change. A single fibronectins gene is present per haploid genome in rodents and mammals. The age-dependent expression of the globulin gene correlates well with the appearance and disappearance of cytoplasmic androgen-binding protein in the liver. The expression of the calbindin-28K gene not only changes during aging, but also in neurodegenerative diseases. Genes that respond to heat stress have been studied in relation to age. Transgenic mice have been used as models to study the types of changes that occur in genes during aging, and the way the responses of genes alter under various types of stress. Protooncogenes encode positive growth regulators, whereas tumor suppressor genes encode growth inhibitors.
