ABSTRACT
Cell functions depend to a large degree on biochemical redox reactions of thiol compounds. As reviewed elsewhere, 15 reduced glutathione (GSH) is needed for support of such essential processes as DNA and protein synthesis, cation pump work, enzyme activity, neurotransmitter release, and carcinogen detoxification. In addition, GSH molecules can give up hydrogen to an oxidant or free radical and form GSSG from pairs of GS− thus protecting proteins and lipoproteins from free radical attack. Recent research also suggests that lipid peroxidation reactions may result in large increases in membrane permeability to calcium ions, thus leading to cell injury or death. 6
