ABSTRACT
Il. Alteration of In Vivo Distribution of Liposomes after Surface Modification with Glycolipids .......................................................................................................... 13 A. Effect of Lipid Composition on Hepatic Uptake of Galactosylated
Liposomes ............................................................................................................. 15 B. Role of Monosialoganglioside (GM!) in Modulating the In Vivo
Behavior of Liposomes ......................................................................................... 16 1. Effect of Liposome Size .................................................................................. 17 2. Possible Mechanism of Prolongation of Circulatory Life of
IV. Application of Glycolipid-Targeted Liposomes to Chemotherapy and Immunotherapy ..................................................................................................... 20 A. Prevention of Experimental Hepatitis .................................................................. 20 B. Treatment of Infectious Diseases ......................................................................... 20 C. As Immunoadjuvant and in Immunotherapy ........................................................ 21
References ............................................................................................................................. 21
Since the discovery that liposomes can be used as effective in vivo delivery vehicles for biologically active molecules and drugs, a number of uses of liposomes as carriers of drug, enzymes, and DNA have been described. 1· 3 However, the targeting of liposomes towards specific tissues is severely limited by the rapid sequestration of liposomes by the reticuloendothelial system (RES). Therefore, efforts have been made in various laboratories to formulate liposomes that bypass the RES with concomitant prolonged circulatory life. We approached this problem in two ways: (1) by cell-specific targeting ofliposomes using various glycolipids; (2) by prolonging the circulatory life of liposomes by attaching polysaccharides. In this chapter we would like to focus on the work carried out by various investigators to alter the in vivo behavior of liposomes using glycolipids and polysaccharides.
