chapter  27
20 Pages

What is the Cost of Nephrotoxicity Associated with Aminoglycosides?

WithJohn M. Eisenberg, Harris Koffer, Henry A. Glick, Margaret L. Connell, Larrye E. Loss, George H. Talbot, Neil H. Shusterman, Brian L. Strom

The component costs of nephrotoxicity were calculated by hospital accounting methods; room and board costs were enumerated with per diem rates. Nephrotoxicity is a well-recognized adverse event associated with the use of aminoglycoside antibiotics. New antibiotics without a known risk of nephrotoxity have been developed as alternatives to aminoglycosides. This chapter provides a case study which compares patients who had nephrotoxicity with patients who did not from a cohort of patients treated with aminoglycoside antibiotics. In this study, physician consultations represent a cost to the payer rather than the hospital, and are reported as an economic effect of aminoglycoside-associated nephrotoxicity. Univariate analyses were done to explore the relationship between each variable and the presence or absence of nephrotoxicity. Regressions were done using nephrotoxicity both as a continuous variable and as a discrete, dummy variable. The potential but undocumented cost of nephrotoxicity related to aminoglycosides is important in assessing the value of an alternative drug.