ABSTRACT
Since the early 1980s, enzymatic dissociation techniques have been employed for the isolation of a variety of retinal cells, including photoreceptors, horizontal cells and bipolar cells. The retinal outer plexiform layer, which consists of synaptic connections among photoreceptors, horizontal cells and bipolar cells, plays a fundamental role in color and spatial-information processings. The clamp simulation is a critical test of the ionic current model, since there is no guarantee that the model can reproduce the current clamp responses, in which the simulation has to be made by using the whole ionic components. The ionic current models are capable of accurately reproducing the voltage- and current-clamp responses of these cells. The chapter concludes that the lateral acceleration for hyperpolarizing response of the horizontal cell was due to the feedback interaction between cone and horizontal cell, that is, the feedback effect causes the high-pass filtering properties in the horizontal cell layer.
