ABSTRACT
This chapter focuses on experiments employing probes intercalated or stacked within the double helix of DNA. The reaction of the DNA bases with radical species generated by radiation, carcinogens, or oxidative stress can lead to mutagenic damage. The efficiency and dynamics of radical transport through the DNA helix therefore hold profound biological implications. The chapter addresses the concerning charge migration through DNA arises that can by using well-defined chemical experiments. Efficient long-range charge transport over remarkable molecular distances has been elucidated in diverse systems utilizing spectroscopy, electrochemistry, and the visualization of chemical reactions. In reactions monitored spectroscopically, electrochemically, and chemically, now demonstrated that a whole series of intercalated reactants with different structural properties can undergo remarkably efficient electron transfer over long molecular distances through the DNA helix. The base stack therefore serves as a bridging medium that is particularly favorable for facilitating long-range electronic coupling.
