ABSTRACT
The CC method has found wide application in kinetics studies of the nucleation, growth and dissolution of calcium phosphate phases. 1–3 The extension of this technique to the simultaneous control of two ionic species has enabled dual constant composition (DCC) studies to be made of concurrent dissolution and growth processes, the simultaneous growth or dissolution of mixed calcium phosphate phases and crystalline phase transformation reactions, 4–6 Since it is now well established that a number of calcium phosphate phases such as octacalcium phosphate (OCP), tricalcium phosphate (TCP), as well as hydroxyapatite (HAP), are involved during many biomineralization processes, 7–9 such reactions may include the formation of calcium phosphate metastable intermediates which subsequently transform into thermodynamically more stable phases as the reactions proceed.
