Effect of Particle Size of Metastable Calcium Phosphates on Crushing Strength of Self-Setting Bioactive Calcium Phosphate Cement

Hydroxyapatite (HAP, Ca₁₀(PO₄)6(OH)₂) is an important mineral component of hard tissues such as teeth and bone. ¹ Therefore, when used in implanted artificial hard tissue, HAP has a high affinity for natural hard tissue in situ and can be molded to fill spaces created by physical damage to the bones and/or teeth. Some attempts ² have been made to prepare bioactive materials for hard tissues using HAP. Yamamura et al. ³ applied HAP beads to bone filler with drug delivering ability, and reported the release of antibiotics from the beads, but it was not long enough for practical therapy since the drug was only absorbed on the surface.