ABSTRACT
A variety of weighting schemes may be considered with any number of possibilities appropriate for a particular set of data or series of data. Fortunately, it is possible to evaluate the weighting schemes chosen by careful observation of the weighted residual plot. In many cases a single equal weight can be applied to each data point. Instead of determining the form or coefficients of the variance model prior to the fitting process, it is possible to determine this during the analysis while determining the parameters of the model. When the error in the data values is relatively large, such as with typical pharmacokinetic or pharmacodynamic data, it becomes important that weighting be considered. The pharmacokinetic model and the error structure for the between and within error are defined in the CONTROL.DAT file. The initial pharmacokinetic parameter values initial within and between variability parameters, and various program control statements are included in the CONTROL.DAT file.
