ABSTRACT

Introduction

Basic GSH Chemistry and Reactions

Antioxidant and Free-Radical Scavenger

Interactions with Other Antioxidants

GSH’s Role in Cancer

GSH Modulation of Receptor Function

Redox Reactions at Ionotropic Receptors

Second-Messenger Activation by GSH

GSH as a Cascading Neuromodulator

GSH as a Neurotransmitter in the CNS

Implications for Multiple Roles of GSH in Normal Synaptic Function

GSH in Neurological Disease

Summary

References