ABSTRACT
Over the past decade synthetic methodologies and reagents in fluorine chemistry have been developed, especially stereocontrolled synthetic methods, enzymatic resolution to synthesize enantiomers, fluoromethylated reagents, and fluorination reagents. This chapter provides an introduction to a trifluoromethyl group of nucleophilic such as α, α, α-trifluorotoluene; 1- phenyl-2,2,2-trifluoroethanol; 1,2:5,6-Di-O-isopropylidene-3-C-trifluoromethyl-α-d-allofuranose, 3-deoxy-l,2:5,6-di-O-isopropyHdene-3-C-trifluoromethyl-α-d-allofuranose; 3-deoxy-1,2:5,6-di-O-isopropylidene-3-C-trifluoromethyl-α-d-allofuranose; 1-phenyl-2,2,2-trifluoroethanol; 5-(trifluoromethyl)-4-oxo-4H-1,3-dioxine-2-spirocyclohexane, benzyl 2-(trifluoromethyl)-3-oxopropionate (enol form); benzyl 2-(trifluoromethyl)-3-oxopropionate (enol form); and N-(2,2,2-trifluoro-1,1-diphenylethyl)acetamide. It also provides an introduction to electrophilic, radical groups such as 1,2,6,7,8,8a-hexahydro-5-(trifluoromethyl)-3-methoxy-8a-methylnaphthalene, 4,4a,5,6,7,8-hexahydro-8-(trifluoromethyl)-4a-methyl-3H-naphthalen-2-one; 4,4a,5,6,7,8-hexahydro-8-(trifluoromethyl)-4a-methyl-3H-naphthalen-2-one; 1-chloro-3,3,3-trifluoro-1-phenylpropane, (E)-3,3,3-trifluoro-1-phenylpropene; (E)-3,3,3-trifluoro-1-phenylpropene; (S)-3-[(S)-2-(Trifluoromethyl)propionyl]-4-(prop-2-yl)oxazolidin-2-one, etc.
