ABSTRACT
Over the past decade synthetic methodologies and reagents in fluorine chemistry have been developed, especially stereocontrolled synthetic methods, enzymatic resolution to synthesize enantiomers, fluoromethylated reagents, and fluorination reagents. This chapter provides an introduction to poly- or perfluorinated group of nucleophilic such as N-AllyI-2-[(tert-butyldimethylsilyl)oxy]-4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoronon-3-yIamine; and 3,3,4,4,4-pentafluoro-2-phenylbutan-2-ol. It also provides an introduction to electrophilic, radical groups such as 6-(1,1,2,2,3,3,4,4,5,5,6,6,6-Tridecafluorohexyl)-1-[(trimethylsilyl)oxy]cyclohex-1-ene, 2-(1,1,2,2,3,3,4,4,5,5,6,6,6-Tridecafluorohexyl)-1-[(trimethylsilyl)oxy]cyclohex-1-ene, 2-(1,1,2,2,3,3,4,4,5,5,6,6,6-Tridecafluorohexyl)cyclohexanone; 6-(1,1,2,2,3,3,4,4,5,5,6,6,6-Tridecafluorohexyl)-1-[(trimethylsilyl)oxy]cyclohex-1-ene; (E)-7,7,8,8,9,9,10,10,10-Nonafluoro-5-iododec-5-en-1-ol, (Z)-7,7,8,8,9,9,10,10,10-Nonafluorodec-5-en-1-ol; (Z)-7,7,8,8,9,9,10,10,10-Nonafluorodec-5-en-1-ol; methyl 2-(1,1,1,2,3,3,3-heptafluoroprop-2-yl)octanoate; 9,9,10,10,11,11,12,12,12-Nonafluoro-7-iodododecane-1,2-diol, 9,9,10,10,11,11,12,12,12-Nonafluorododecane-1,2-diol; and 9,9,10,10,11,11,12,12,12-Nonafluorododecane-1,2-diol. The chapter discusses carbon-carbon bond-forming reactions such as (4R* ,5R*)-5-(Pentafluoroethyl)-4-(methoxycarbonyl)-5-phenyl-2-oxazoline; and (R)-3-[(S)-4,4,4-Trifluoro-4-(trifluoromethyl)-3-hydroxy-2-methylbutyryl]-4-(prop-2-yl)oxazolidin-2-one, (R)-4,4,4-Trifluoro-4-(trifluoromethyl)-2-methylbutane-1,3-diol.
