ABSTRACT
This chapter presents the responsibilities of the laboratory supervisor and quality assurance officer relating to the calibration checks, and the final validation and approval of the reporting values. Quality control is the check of the result of an analytical measurement. It helps to indicate that the reported value is correct and acceptable. Analytical blanks measure the degree of contamination and seriously affect the accuracy of low-level trace determinations. Calibration in chemical measurements refers to the process by which the response of a measurement system is related to the different concentrations of the analyte of interest. Duplicates and split samples are used to measure the precision of the analytical system. Titrimetric or volumetric analyses are very sensitive for carefully cleaned and properly used glassware. Titrant solutions must be prepared with extreme care and standardized for exact normality each time before use.
