There are two distinct ways of modelling language disorders. One is the structuralist approach where there is an attempt to associate language impairment with brain areas, often, but not always, using group studies. The second approach is to somewhat disregard this relationship with brain structure but instead to concentrate on analysing the breakdown of the process through the use of single-case studies. These are extreme ends of a continuum, but this division in styles of research needs to be considered more in language than any other function. In this chapter there is an attempt to integrate these two approaches.