ABSTRACT
The role of serotonin (5–HT) in human feeding can be explored using drugs which, in animals, act on central 5–HT neurotransmission. Such drugs can either enhance transmission by providing precursor loading (tryptophan), by increasing release from presynaptic neurones (fenfluramine) (Garattini and Samanin, 1976) or by blocking its reuptake (fluoxetine) (Goudie, Thornton & Wheeler, 1976), or reduce transmission by blocking post–synaptic 5–HT receptors (metergoline, methysergide) (Blundell and Latham, 1980; Garattini, 1986).
