ABSTRACT

The evaluation of the effects of serotonergic drugs on the sexual behaviour of the female rat began with the work of Meyerson, who in the early 1960’s set forth the hypothesis that serotonergic activity inhibits the expression of lordosis behaviour (Meyerson, 1964a,b,c). Lordosis is the downward flexion of the back and lifting of the rump and tail that may be displayed by a female rat in response to the mounting and pelvic thrusting of a male. The display of lordosis is generally regarded as an indicator of sexual receptivity in the female rat.