ABSTRACT

Memory allows us to benefit from the past, interpret the present, and predict the future. Elucidating the behavioral, physiological, biochemical and molecular processes involved in memory remains one of the most challenging problems in all of neuroscience. The explicit goal of this research is to provide a more complete understanding of the neurobiology of normal memory processes. However, an important corollary assumption is that this strategy will reveal the substrates of memory disorders which are associated with neurological and psychiatric diseases. For example, memory dysfunction is commonly observed in a variety of neurodegenerative disorders including Alzheimer's and Huntington's diseases (see Table 13.1).