ABSTRACT
Disruptions of septohippocampal circuitry have profound behavioral, electrophysiological, and anatomical effects. Various research efforts have been directed at ameliorating the deficits caused by such damage by introducing neural and/or nonneural tissues. These implantation procedures have included the introduction of fetal brain tissue (Björklund & Stenevi, 1977; Gage, Björklund, Stenevi, & Dunnett, 1985), amnionic membrane (Gage et al., 1988), genetically engineered fibroblasts (Gage et al., 1987), chromaffin cells from the adrenal gland (Freed et al., 1981) or direct administration of nerve growth factor (NGF; Hefti, 1986; Will & Hefti, 1985; Will, Hefti, Pallage, & Toniolo, 1988). Implanted tissue may also place neurotrophic factors (NTFs) such as NGF into the vicinity of the lesion.
