chapter  5
Novel (Atypical) Antidepressants
Pages 47

In contrast to the TCAs, fluoxetine selectively blocks serotonin reuptake, with no effect on norepinephrine uptake. It also has no effect on norepinephrine or dopamine reuptake.10 Its site of action is believed to be the serotonin reuptake pump as opposed to the neurotransmitter receptor site. Chemically, it is unrelated to the TCAs.