A Survey of Animal Models to Develop Novel Antithrombotic Agents

The development of antithrombotic agents requires preclinical assessment of the biochemical

and pharmacological effects of these drugs. It is important to note that the second-and third-

generation antithrombotic drugs are devoid of in vitro anticoagulant effects, yet in vivo, by virtue

of endogenous interactions, these drugs produce potent antithrombotic actions. The initial belief

that an antithrombotic drug must exhibit in vitro anticoagulant activity is no longer valid. This

important scientific observation has been possible only because of the availability of animal

models.