ABSTRACT

Combinatorial chemistry and high-throughput screening (HTS) have become the fastest growth areas in pharmaceutical development. Combinatorial chemistry is a collection of technologies and disciplines. The ultimate objectives are to prepare compound libraries so that active leads can be identified more quickly, in greater numbers, and at lower costs. Over the past few years there has been an explosion in the number of companies developing, utilizing, and/ or offering the various techniques for use in the lab. Press releases announce activities in these areas on a daily basis. It is a challenge to keep up with the current players, whether they are developing or licensing proprietary technologies, establishing collaborative relationships, commercializing products, acquiring or selling business operations, or any of a number of other activities.