Characterization of Biomolecular Interfaces with Scanning Electrochemical Microscopy: From Model Monolayers to Tissues and Cells

Scanning electrochemical microscopy (SECM) has developed into a powerful technique for quantitative investigations of interfacial physicochemi cal processes, in a wide variety of areas, as considered in several recent reviews [1-6]. This chapter will provide a background to SECM and its application in characterizing biomolecular films and related interfaces. Since many SECM techniques are generic, we consider their application to biomolecular systems in general.