ABSTRACT
Frontal and inferior temporal cortex can also communicate via multisynaptic pathways through the basal forebrain. As discussed in Chapter 7, the basal forebrain is ideally suited for multisynaptic subcortical communication between these two cortical areas, receiving a strong projection from frontal cortex (Mesulam & Mufson, 1984; Ongur, An, & Price, 1998; Rempel-Clower & Barbas, 1998) and in turn projecting to inferior temporal cortex (Mesulam, Mufson, Levey, & Wainer, 1983; Webster, Bachevalier, & Ungerleider, 1993). There are also projections from lateral hypothalamic cells to contralateral cells of the substantia innominata (Cullinan & Zaborszky, 1991). These crossed projections, along with the strong interconnection of basal forebrain with midbrain areas (Russchen, Amaral, & Price, 1985) which are themselves bilaterally integrated, allow the basal forebrain to be a route of communication between frontal lobe and inferior temporal cortex both within the same hemisphere and between hemispheres.
