ABSTRACT

A decade after publication of the first edition, Handbook of Venoms and Toxins of Reptiles responds to extensive changes in the field of toxinology to endure as the most comprehensive review of reptile venoms on the market. The six sections of this new edition, which has nearly doubled in size, complement the original handbook by presenting current information from many of the leading researchers and physicians in toxinology, with topics ranging from functional morphology, evolution and ecology to crystallography, -omics technologies, drug discovery and more. With the recent recognition by the World Health Organization of snakebite as a neglected tropical disease, the section on snakebite has been expanded and includes several chapters dealing with the problem broadly and with new technologies and the promises these new approaches may hold to counter the deleterious effects of envenomation.

This greatly expanded handbook offers a unique resource for biologists, biochemists, toxicologists, physicians, clinicians, and epidemiologists, as well as informed laypersons interested in the biology of venomous reptiles, the biochemistry and molecular biology of venoms, and the effects and treatment of human envenomation.

section Section I|96 pages

Introduction and Technologies Used in Toxinology

chapter 1|16 pages

Reptile Venoms and Toxins

Unlimited Opportunities for Basic and Applied Research

chapter 6|6 pages

Envenomations and Treatment

Translating between the Bench and the Bedside

section Section II|78 pages

Venom Gland Structure, Systematics and Ecology

chapter 8|24 pages

Reptile Venom Glands

Form, Function, Future, Concepts and Controversies

section Section III|174 pages

Reptile Venom Non-Enzymatic Toxins

chapter 18|14 pages

Reptile Venom C-Type Lectins

chapter 21|16 pages

Cobra Venom Factor

Structure, Function, Biology, Research Tool, and Drug Lead

section Section IV|120 pages

Reptile Venom Enzyme Toxins

chapter 25|8 pages

Snake Venom Matrix Metalloproteinases (svMMPs)

Alternative Proteolytic Enzymes in Rear-Fanged Snake Venoms

section Section V|152 pages

Global Approaches to Envenomations and Treatments

chapter 31|14 pages

Snakebite Envenomation as a Neglected Tropical Disease

New Impetus for Confronting an Old Scourge

chapter 36|16 pages

Snakebite Envenomation in Central America

Epidemiology, Pathophysiology and Treatment

chapter 37|22 pages

Snakebite in Southeast Asia

Envenomation and Clinical Management

chapter 38|12 pages

Snake Envenomation

Therapy and Challenges in India

chapter 39|20 pages

Snakebite in Africa

Current Situation and Urgent Needs

section Section VI|32 pages

Reptile Venoms – Production and as a Source of Therapeutics

chapter 41|12 pages

Large-Scale Snake Colonies for Venom Production

Considerations and Challenges