ABSTRACT

Bayesian Approaches in Oncology Using R and OpenBUGS serves two audiences: those who are familiar with the theory and applications of bayesian approach and wish to learn or enhance their skills in R and OpenBUGS, and those who are enrolled in R and OpenBUGS-based course for bayesian approach implementation. For those who have never used R/OpenBUGS, the book begins with a self-contained introduction to R that lays the foundation for later chapters.

Many books on the bayesian approach and the statistical analysis are advanced, and many are theoretical. While most of them do cover the objective, the fact remains that data analysis can not be performed without actually doing it, and this means using dedicated statistical software. There are several software packages, all with their specific objective. Finally, all packages are free to use, are versatile with problem-solving, and are interactive with R and OpenBUGS.

This book continues to cover a range of techniques related to oncology that grow in statistical analysis. It intended to make a single source of information on Bayesian statistical methodology for oncology research to cover several dimensions of statistical analysis. The book explains data analysis using real examples and includes all the R and OpenBUGS codes necessary to reproduce the analyses. The idea is to overall extending the Bayesian approach in oncology practice. It presents four sections to the statistical application framework:

 

  • Bayesian in Clinical Research and Sample Size Calcuation
  • Bayesian in Time-to-Event Data Analysis
  • Bayesian in Longitudinal Data Analysis
  • Bayesian in Diagnostics Test Statistics

 

This book is intended as a first course in bayesian biostatistics for oncology students. An oncologist can find useful guidance for implementing bayesian in research work. It serves as a practical guide and an excellent resource for learning the theory and practice of bayesian methods for the applied statistician, biostatistician, and data scientist.

part I|61 pages

Bayesian in Clinical Research

chapter Chapter 1|9 pages

Introduction to R and OpenBUGS

chapter Chapter 2|17 pages

Sample Size Determination

chapter Chapter 3|8 pages

Study Design-I

chapter Chapter 4|8 pages

Study Design-II

chapter Chapter 5|15 pages

Optimum Biological Dose Selection

part II|65 pages

Bayesian in Time-to-Event Data Analysis

chapter Chapter 6|21 pages

Survival Analysis

chapter Chapter 7|9 pages

Competing Risk Data Analysis

chapter Chapter 8|13 pages

Frailty Data Analysis

chapter Chapter 9|17 pages

Relative Survival Analysis

part III|53 pages

Bayesian in Longitudinal Data Analysis

chapter Chapter 10|11 pages

Longitudinal Data Analysis

chapter Chapter 11|10 pages

Missing Data Analysis

chapter Chapter 12|15 pages

Joint Longitudinal and Survival Analysis

chapter Chapter 13|13 pages

Covariance modeling

part IV|44 pages

Bayesian in Diagnostics Test Statistics

chapter Chapter 14|12 pages

Bayesian Inference in Mixed-Effect Model

chapter Chapter 15|11 pages

Concordance Analysis

chapter Chapter 16|18 pages

High-Dimensional Data Analysis