ABSTRACT
Recent advances in immunology and biology have opened new horizons in cancer therapy, included in the expanding array of cancer treatment options, which are immunotherapies, or cancer vaccines, for both solid and blood borne cancers. Cancer Vaccines: Challenges and Opportunities in Translation is the first text in the field to bring immunotherapy treatments from the laboratory trial to the bedside for the practicing oncologist.
Cancer Vaccines: Challenges and Opportunities in Translation:
- Critically analyzes the most promising classes of investigational immunotherapies, integrating their scientific rationale and clinical potential
- Discusses "theranostics" as pertaining to immunotherapy, i.e., using molecular diagnostics to identify patients that would most likely benefit from a therapy
- Presents the new paradigm of biomarker guided R&D and clinical development in immunotherapy of cancer
- Reviews bottlenecks in translational process of immunotherapies and offers strategies to resolve them
SECTION I - Basic Aspects: Tumor Antigens and Preclinical Modelling. 1. Factoring in antigen processing in designing anti-tumor T-cell vaccines. 2. Outlining the gap between preclinical models and clinical situation. SECTION II - Cell Based, Anti-infectious and Personalized Vaccines. 3. THERAPEUTIC AND PROPHYLACTIC CANCER VACCINES - EMERGING PERSPECTIVES FROM ALLOGENEIC AND INFECTIOUS DISEASE VACCINES. 4. Personalized Cancer Vaccines. 5. Dendritic cell vaccines for gliomas. SECTION III. INTRACEREBRAL HEMORRHAGE (ICH). 6. Peptide based active immunotherapy in cancer. 7. Multimodality Immunization Approaches to Improve on DNA Vaccines for Cancer. 8. Bidirectional Bedside Lab Bench Processes and Flexible Trial Design as a Means to Expedite the Development of Novel Immunotherapeutics. 9. Diagnostic approaches for selecting patient-customized therapies, obviating tumor variability to maximize therapeutic effect.
