ABSTRACT

Gamma-hydroxybutyrate (GHB) has come a long way since early experiments in animals where it was found to induce a sleep-like state and from its use in general anaesthesia in human subjects. It has been found to be a naturally-occurring compound in the brain, a metabolite of GABA, the emerging ubiquitous inhibitory neurotransmitter. This has opened

chapter 4|13 pages

Membrane transport of γ-hydroxybutyrate

chapter 10|22 pages

Therapeutic uses of γ-hydroxybutyrate

chapter 12|25 pages

4-Hydroxybutyric aciduria

chapter 13|21 pages

γ-Hydroxybutyrate and oxidative stress