ABSTRACT
Serves as a comprehensive review to the substantial impact of gene amplification in molecular biology, genetic engineering and medical science. The book covers the mechanism of gene amplification, organization and structure of amplified genes.
TABLE OF CONTENTS
chapter |26 pages
Introduction to Gene Amplification
Historical Background and Biological Perspective
part I|68 pages
Organization and Structure of Amplified Genes
chapter 1|14 pages
Cytogenetic Consequences of Gene Amplification
HSRs and DMs in Antifolate-Resistant and Multidrug-Resistant Chinese Hamster and Mouse Cells and in Human Neuroblastoma Cells with Amplified N-myc Proto-Oncogenes
part II|218 pages
Gene Amplification and Drug Resistance
part III|56 pages
Amplification of Transferred Genes
part IV|70 pages
Gene Amplification and Cancer
chapter 33|10 pages
Gene Amplification in Nontumorigenic and Tumorigenic Mammalian Cells
Relationship to Carcinogenesis
part V|94 pages
The Mechanism of Gene Amplification
chapter 39|14 pages
Amplisomes
Novel Submicroscopic Extrachromosomal Elements Containing Amplified Genes
chapter 40|20 pages
Cytogenetic and Molecular Dynamics of Mammalian Gene Amplification
Evidence Supporting Chromosome Breakage as an Initiating Event
