Recent Developments in Therapeutic Drug Monitoring and Clinical Toxico

Book

Recent Developments in Therapeutic Drug Monitoring and Clinical Toxicology

ABSTRACT

Papers from the Second International Conference on TDM Toxicology (date and place not stated) describe research on various aspects of therapeutic monitoring pharmacology, selected high-performance liquid chromatographic methods, antiepileptics, substances subject to abuse, inorganics. Over 100 contr

TABLE OF CONTENTS

part I|164 pages

Therapeutic Monitoring

chapter 1|6 pages

A Case for Therapeutic Drug Monitoring

chapter 2|6 pages

A Clinical Chemistry Therapeutic Drug Monitoring Service

chapter 3|4 pages

A Successful Experience in Therapeutic Drug Monitoring

chapter 4|8 pages

The Impact of an Active Laboratory Approach on Therapeutic Drug Monitoring

chapter 5|8 pages

Assessment of the Introduction of a Therapeutic Handbook in a Teaching Hospital

chapter 6|2 pages

A Multidisciplinary Approach to Therapeutic Drug Monitoring Services

chapter 7|6 pages

An Audit of a Therapeutic Drug Monitoring Service

chapter 8|8 pages

Free Therapeutic Drug Monitoring

chapter 9|2 pages

Population Data in Therapeutic Drug Monitoring

chapter 10|10 pages

Therapeutic Drug Monitoring in Pregnancy

chapter 11|2 pages

Issues in Therapeutic Drug Monitoring of Digoxin in Children

chapter 12|6 pages

Practical Aspects of Neonatal Therapeutic Drug Monitoring

chapter 13|8 pages

Evaluation of Erythropoietin Determination as a Method of Diagnosis and Therapeutic Monitoring

chapter 14|8 pages

Clinical Validation of a Computerized Method for Therapeutic Monitoring of Aminoglycoside Therapy

chapter 15|6 pages

Evaluation of a New Software Package for the Individualization of Amikacin Dosing in Intensive-Care-Unit Patients

chapter 16|4 pages

Evaluation of the Abbott Base Pharmacokinetic System for the Individualization of Amikacin, Vancomycin, and Theophylline Dosing

chapter 17|8 pages

The Impact of the Cardiac Arrhythmia Suppression Trial (CAST) on Antiarrhythmic and Cardioactive Drug Monitoring

chapter 18|6 pages

Clinical Usefulness of Imipramine and Desipramine Serum-Level Monitoring in Patients Treated for Endogenous Depression

chapter 19|6 pages

Light-Induced Racemization of the Diastereoisomeric Pairs of Thioridazine 5-Sulfoxide: Origin of Artifacts in the TDM of Thioridazine

chapter 20|6 pages

Cephalosporins

chapter 21|10 pages

Therapeutic Drug Monitoring for 6-Mercaptopurine: What, When, and How?

chapter 22|14 pages

Selection of Optimal Specifications for Cyclosporine Monitoring: A Study of Variation in Pharmacokinetic Parameters in Response to Dose Changes and Prediction of Adverse Clinical Events Using Four Different Assay Methods

chapter 23|6 pages

Monitoring of Plasma Glucocorticosteroids as an Indicator of Noncompliance in Pediatric Renal Transplant Recipients

chapter 24|6 pages

Therapeutic Drug Monitoring: Role of Alpha1-Acid Glycoprotein (AGP) Binding

chapter 25|6 pages

Impact of a Clinical Pharmacokinetic Service on Patients Treated with Aminoglycosides: A Cost-Benefit Analysis

part II|110 pages

Pharmacology

chapter 26|10 pages

Pregnancy in Cyclosporine-Treated Renal Transplant Recipients

chapter 27|6 pages

Cyclosporine Neurotoxicity and Hypomagnesemia

chapter 28|4 pages

The Role of Lipids and Cyclosporine A in Adverse Side Effects in Pediatric Liver Transplant Patients

chapter 29|6 pages

In Vitro Immunomodulatory Effect of Doxycycline

chapter 30|6 pages

Pharmacology and Toxicology of Quinolones

chapter 31|4 pages

Metoclopramide as Inhibitor of Serum Cholinesterase

chapter 32|8 pages

Cyclosporine A–Drug Interactions

chapter 33|4 pages

Relationship Between Q-T Interval and Serum Concentrations in a Case of Sotalol Poisoning

chapter 34|6 pages

Vancomycin Pharmacokinetics in Hematologic Cancer Patients

chapter 35|6 pages

Rifampicin Binding to Serum Proteins in Normal and Brucellosic Individuals

chapter 36|12 pages

Comparison by Computer Simulation of Five Different Infusion Regimens of Thiopental as Primary Agent to Reduce Intracranial Hypertension

chapter 37|8 pages

Influence of Cisplatin Infusion Rate on Local Availability of the Drug

chapter 38|4 pages

Determinants of Urine Caffeine Concentration: Implications for Monitoring Caffeine Intake During Sports Events

chapter 39|6 pages

Monitoring of Methotrexate Given in Continuous i.v. Infusion to Pediatric Cancer Patients

chapter 40|8 pages

Chirality in Pharmacokinetics and Therapeutic Drug Monitoring

chapter 41|6 pages

A Stereoselective HPLC Method for the Determination of Total and Free Disopyramide in Serum Using an α1-Acid Glycoprotein Column

chapter 42|4 pages

Direct Determination of Selenium by Graphite Furnace Atomic Absorption Spectrometry with Deuterium Background Correction

part III|114 pages

Selected High-Performance Liquid Chromatographic Methods

chapter 43|8 pages

HPLC Reference Method for Theophylline: Calibration by Use of Standard Addition

chapter 44|6 pages

Comparison of Vancomycin Concentration Measured in Serum Versus Plasma

chapter 45|6 pages

Pharmacokinetics of Oral Gemfibrozil in Healthy Volunteers

chapter 46|10 pages

Evaluation of a Fluorescence Polarization Immunoassay for Use in Monitoring Plasma Dothiepin Levels in Overdose Cases

chapter 47|6 pages

Determination of Fluoxetine and Norfluoxetine in Serum by Liquid Chromatography with Fluorescence Detection

chapter 48|8 pages

HPLC Analysis of Gabapentin: A New Anticonvulsant Drug

chapter 49|4 pages

Clonazepam and 7-Aminoclonazepam in Human Plasma

chapter 50|12 pages

Analysis of Benzodiazepines and Tricyclic Antidepressants in Whole Blood Using a Common Solid-Phase Clean-Up and a Common Mobile Phase

chapter 51|4 pages

Detection of Urinary Benzodiazepines by Radioreceptor Assay

chapter 52|6 pages

Comparison of Specific Radioimmunoassays for Cyclosporine Measurement

chapter 53|6 pages

Whole-Blood Cyclosporine Concentration Measured by Radioimmunoassay Using Polyclonal and Monoclonal Antibodies and Risk of Acute Graft-Versus-Host Disease After Allogeneic Bone Marrow Transplantation

chapter 54|6 pages

Fluorescence Polarization Immunoassay for Measurement of Cyclosporine A

chapter 55|8 pages

A Homogeneous Enzyme Immunoassay for Phenytoin (CEDIA) and Application on the Hitachi 704

chapter 56|8 pages

A Homogeneous Enzyme Immunoassay for Theophylline (CEDIA) and Application on the Hitachi 704

chapter 57|8 pages

A Homogeneous Enzyme Immunoassay for Phenobarbital (CEDIA) and Application on the Hitachi 704

chapter 58|6 pages

An HPLC Method for the Quantitation of Propafenone and Its Metabolites in Pediatric Samples

part IV|92 pages

Antiepileptics

chapter 59|10 pages

Distribution of Phenytoin in Different Regions of the Brain and in the Serum: Analysis of Autopsy Specimens from 25 Epileptic Patients

chapter 60|8 pages

Prediction of the Free Serum Concentrations of Phenytoin, Phenobarbital, Carbamazepine, and Carbamazepine-10,11-epoxide in Patients on Valproic Acid Co-medication

chapter 61|6 pages

Steady-State Pharmacokinetics and Dosing of Phenytoin and Phenobarbital in Patients

chapter 62|6 pages

Valproic Acid Enhances Lipid Peroxidation in Rat Liver, in Vivo

chapter 63|12 pages

Carbamazepine Drug Interactions: The Influence of Concurrent Drug Therapy on Serum Concentrations of Carbamazepine and Its Epoxide Metabolite

chapter 64|4 pages

Comparison of Carbamazepine and Phenytoin Effects on Multimodal Evoked Potentials

chapter 65|6 pages

Antiepileptic Effect and Serum Levels of Zonisamide in Epileptic Patients with Refractory Seizures

chapter 66|8 pages

Metabolism and Pharmacokinetic Study of the Antiepileptic Drug Halonal

chapter 67|8 pages

Metabolic and Pharmacokinetic Study of the Antiepileptic Drug Phuphemid

chapter 68|10 pages

Performance of Techniques for Measurement of Therapeutic Drugs in Serum: A Comparison Based on External Quality Assessment Data

chapter 69|6 pages

Simultaneous Determination of Clobazam and Its Metabolite Desmethylclobazam in Serum by Gas Chromatography with Electron-Capture Detection

chapter 70|6 pages

Analysis of Fluoxetine and Its Metabolite Norfluoxetine in Serum by Reversed-Phase HPLC, with Ultraviolet Detection

part V|132 pages

Substances (Drugs) Subject to Abuse

chapter 71|6 pages

A Rapid Alcohol Test for On-Site Testing

chapter 72|8 pages

Therapeutic Monitoring of Alcohol Withdrawal During Diazepam Loading-Dose Treatment

chapter 73|6 pages

Clinical Monitoring of Ethanol Metabolism in Humans

chapter 74|10 pages

Development of Sensitive HPLC Assays for the Analysis of Steroids in In-Vitro and In-Vivo Studies

chapter 75|2 pages

Importance of Creatinine for Urine Quality Control in Determination of Abused Drugs

chapter 76|6 pages

Delta-9-Tetrahydrocannabinol: Pharmacokinetics and Pharmacodynamics

chapter 77|6 pages

Evaluation of a Thin-Layer Chromatographic Method for the Detection of Cannabinoid (THC) Metabolite Using a Microcolumn/Disk Extraction Technique

chapter 78|10 pages

Sensitivity and Specificity of Techniques Used to Detect Drugs of Abuse in Urine

chapter 79|10 pages

A Cost-Effective EMIT Method for Qualitative Drug Abuse Analysis Performed in the Technicon Chem-1 Analyzer

chapter 80|8 pages

Development, Implementation, and Management of a Drug Testing Program in the Workplace

chapter 81|10 pages

Hair Analysis: Techniques and Potential Problems

chapter 82|4 pages

Forensic Hair Analysis: Cocaine

chapter 83|6 pages

Hair Test to Verify Gestational Cocaine Exposure

chapter 84|2 pages

Doping Control and Olympic Games

chapter 85|22 pages

Hair Analysis for Drugs of Abuse: Decontamination Issues

chapter 86|6 pages

Analysis of Anabolic Steroids in Food and Biological Materials

chapter 87|8 pages

Pharmacogenetics and Interpretation of Toxicological Results

part VI|34 pages

Inorganics

chapter 88|6 pages

Selenium: An Overview from the Laboratory Perspective on Its Role in Infant Health

chapter 89|6 pages

Serum Magnesium Concentrations After Three Different Maximal Exercises

chapter 90|8 pages

Relationship of Zinc to Growth and Development

chapter 91|4 pages

Clinical Usefulness of Magnesium (II) Lymphocytes Content Determination in Dilated Myocardial Disease

chapter 92|4 pages

Aluminum Bone Content in Patients Undergoing Renal Hemodialysis

chapter 93|4 pages

Lead—Unsafe at Any Level?

part VII|140 pages

Miscellaneous

chapter 94|6 pages

State of the Art of the Metrological Quality of Analytical Methods for Drug Assay

chapter 95|8 pages

Documentation of European Drugs with Standardized TLC System

chapter 96|8 pages

Eurotox Proficiency Study 1990

chapter 97|6 pages

Statistical Approaches to Accuracy in Drug Screening

chapter 98|6 pages

Synthetic Calibrator Matrices in Immunoassays

chapter 99|8 pages

New Delivery Methods for Intravenous Drugs

chapter 100|12 pages

Unified Liquid Chromatographic and Gas Chromatographic Assays for Therapeutic Drug Monitoring and Toxicology

chapter 101|10 pages

Biological Indicators of Environmental Cancer Risk

chapter 102|6 pages

Lipid and Lipoproteins After Maximal Exercise

chapter 103|4 pages

Lipoproteins in Rats with Uranyl Acetate-Induced Acute Renal Failure

chapter 104|4 pages

Effect of Sodium Metavanadate on Plasma Proteins and Fructosamine in Streptozotocin-Induced Diabetic Rats

chapter 105|6 pages

Binding of Cadmium to Albumin and Its Inhibition by Zinc, Copper. EDTA, and Penicillamine

chapter 106|6 pages

Random Sequential Mechanism of Human Placental Glutathione S-Transferase

chapter 107|4 pages

Imipramine Receptors: Protein Influence and Membrane Versus Whole Platelet Binding

chapter 108|8 pages

Chemical Structure and Hepatotoxicity of Nonsteroidal Antiinflammatory Drugs in Isolated Liver Cells

chapter 109|8 pages

DNA Synthesis Stimulation by Aluminum Ions in Human Fibroblasts Cultured in Vitro

chapter 110|6 pages

Modulation of Human Microsomal Aminopyrine N-Demethylase Activity by Cimetidine. Caffeine, and Demethylated Metabolites

chapter 111|8 pages

Drug Metabolism as an Index of Liver Function

chapter 112|6 pages

Transitory Effect of Antiepileptic Drugs on Carnitine Homeostasis in Mouse Serum and Tissues

chapter 113|8 pages

Influence of the Inhalation of High Concentrations of Oxygen on Infections by Aeruginosas peudomonas: Experimental Study