ABSTRACT

This chapter pertains to the spatiotemporal distribution of hematopoietic stem cells (HSCs) which are the starting point for the various cells in the bloodstream. A hematopoietic stem cell is a cell isolated from the blood or bone marrow that can renew itself, can differentiate to a variety of specialized cells, can mobilize out of the bone marrow into circulating blood, and can undergo programmed cell death, called apoptosis. This chapter presents a variant of a delayed partial differential equation model coded in R as a main program and a delayed partial differential equation/method of lines (MOL) routine in the MOL format.